Abstract

NUNEZ COPO, Antonio César; FROMETA MONTOYA, Carmen  and  HECHAVARRIA ESTENOZ, Dulce. Environmental and genetic factors associated to paranoid schizophrenia in "28 de septiembre" health area. Rev Cubana Med Gen Integr [online]. 2013, vol.29, n.2, pp.141-150. ISSN 0864-2125.

Background: schizophrenia is an illnes that is marked by a variable expressiveness wihc suggests the existence of heterogeneus etiological factors and physiopathological processes. A hypothesis of gene-enviroment interaction is being considered as it main way of transmission. Objetive: to determine the possible enviroment and genetic factors associated with the illness onset. Methods: it carriedout an analytical-observational study of cases and controls on the area"28 de Septiembre" of Santiago de Cuba during the four month period of january-april of 2011.It included 40 patients with a diagnosis of paranoic schizophrenia recorded on the Psychiatrist service selected randomly stratified by sex, as well as 80 controls without this diagnosis to determine the possible enviromental and genetic factors that could have influenced on the appearance of the disease. Chi square test was applied and the relative opportunity (odds ratio) by trist interval. Results: the civil status of single resulted significative at the appearing and three quarters of the cases studied presented a stressing went at the beginning of the disease. there was an asociation of the familiar antecedents of the affection in the cases. It was recorded a greater percentage affected persons in familiar of first degree in both groups difference that resulted to be more significative on the cases. It was also observed familiar addition of the affection more frequent on the cases than of the control. Conclusions: it was demonstrated that there is an association of the family antecedents of the illness in all the cases. There was more percent of affected people in first degree families in both groups. Family illness aggregation was observed. Prenatal antecedents increase the risk and pre-morbid patterns since childhood were hightly significant.

Keywords : paranoic schizoprenia; genetic and not genetic factors; familiar antercedents; familiar agregations.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )