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Revista Cubana de Medicina General Integral

Print version ISSN 0864-2125On-line version ISSN 1561-3038


ZAMBRANO-URBANO, Jose L.; OCAMPO-CHAPARRO, José M.  and  MONTERO, Leonardo. Neuroleptospirosis with Pericarditis and Intrahepatic Cholestasis (Weil syndrome). Rev Cubana Med Gen Integr [online]. 2020, vol.36, n.2, e1162.  Epub July 01, 2020. ISSN 0864-2125.


Weil syndrome is a serious form of the bacterial infection caused by the Leptospira bacterium; this is known as leptospirosis. This is characterized by multiple organ dysfunction; for example, the liver, kidney, muscles, of serous type, or the neurological system, in this case called neuroleptospirosis, which produces a very high mortality when adequate diagnosis and treatment are not provided.


To describe the clinical manifestations, complementary paraclinic practice and treatment of a patient with Weil syndrome, as a rare condition.

Clinical case:

23-year-old patient who presents with acute febrile syndrome associated with optic neuritis, chest pain, and paraclinical symptoms obviously consistent liver and cardiac involvement. The diagnosis of Weil syndrome is confirmed, specifically defined by neuroleptospirosis, pericarditis, and intrahepatic cholestasis.


Through a clinical case of Weil syndrome, the multisystem involvement of complications associated with leptospirosis is described, along with its unusual manifestations, such as neuroleptospirosis, pericarditis, and intrahepatic cholestasis.

Keywords : neuroleptospirosis; Weil syndrome; leptospirosis; acute febrile syndrome.

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