Abstract

MOLINA CISNEROS, Ceija; ALEMANY RUBIO, Ernesto; TRIANA CASADO, Idalia  and  GONZALEZ RODRIGUEZ, Liudmira. New topical steroid for the treatment of macular edema. Rev Cubana Oftalmol [online]. 2013, vol.26, n.3, pp. 452-465. ISSN 0864-2176.

The main pillar of the treatment of both the postsurgical and endogenous eye inflammations is based on the use of steroids. Although these drugs are effective, their use has risks such as ocular hypertension and accelerated formation of cataracts, fundamentally in the case of stronger steroids such as prednisolone and betamethasone. This review was aimed at expanding the knowledge on biochemistry and the development of difluprednate, a new highly potent synthetic steroidal drug that has been approved by the Food and Drug Administration (FDA) to treat macular edema after the anterior segment surgery. Some aspects of this off-label drug were analyzed such as pharmacokinetics, metabolism, ocular distribution of drug and usefulness in phases I, II and II of clinical assays on the use of these drugs in patients with postoperative inflammations both in the anterior and the posterior segments and with anterior uveitis.

Keywords : topical steroid; macular edema; eye inflammations.

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