Abstract

ACOSTA VALDES, Pedro Pablo; VARONA RODRIGUEZ, Francisco; GARCIA SANCHEZ, José  and  PEREZ CRUZ, Beatriz. Pancreatic antiislet antibodies in diabetes type I and families of first grade. AMC [online]. 2002, vol.6, n.3, pp.235-245. ISSN 1025-0255.

A crosssectional study about the presence of antibodies anti-islets pancreatic by the indirect inmunofluorescent method with prolonged incubation in families of first grade of diabetic children type 1, of diabetic of recent prognosis assisted at pediatric Specialties Polyclinic of Camagüey, and to a control group withoud antecedentes of diabetes mellitus was performed. They all were carried out aq previous survey. A high frequency of pancreatic antiislets antibodies in diabetics type ! of recent prognosis (p< 0, 001), in relation with parents of diabetics type 1 (FPG) and contol (80 % vs 5, 7 % and 0, 0 % respectively) was found. This frequency was also superior in FPG in comparison to control ( p= 0, 045) there were not differences when relating ICA with the Kindred, family history of diabetes, type 1 and 2, age and sex of FPG. Our results indicate that pacreatic antiislet antibodies (ICA) is a good marker of the destruction process of pancreatic B cells in diabetes type ! of recent diagnosis, and the presence of them in FPG may identify families with a higher probabilty for developing diabetes type 1.

Keywords : DIABETES MELLITUS; INSULIN DEPENDENT; ISLOTES OF LANGERHANS.

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