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Revista Archivo Médico de Camagüey

On-line version ISSN 1025-0255


ARREDONDO BRUCE, Alfredo  and  AMORES CARRATE, Jacqueline. Metabolic syndrome in current clinic. AMC [online]. 2007, vol.11, n.6. ISSN 1025-0255.

 A bibliographical revision about the metabolic syndrome is performed which is been considered a great factor since its description as X Syndrome in 1988, also known as insulin resistance syndrome, and nowadays as metabolic syndrome which is clinically recognized by abdominal obesity, elevated triglycerides, atherogenetic dyslipidemy, (low levels of lipoproteins of elevated density - cholesterol (HDL-C) high blood pressure, high glucose levels, and/or insulin resistance. This syndrome also is characterized by a prothrombotic and inflammatory state, affects approximately to the 24% of the adult population in the United States; according to the criteria of the Third National Health and Nutrition Examination Survey (NHANES III), near 47 million people have this syndrome. The pathogenesis is given by a complex of mutually interactive actions, between obesity and insulin resistance is presented since along  time ago in the pathogeny of the metabolic syndrome, the pathophysiology includes: insulin resistance, atherogenetic dyslipidemy, are also frequent prone particles to the oxidation as the chylomicrons of fast and postprandial and glycolysied LDL particles, hypertension, proinflammatory state, with an increase of the reactant acute phase (C-reactive protein CRP); and prothrombotic state, with an increase of the inhibitor activator of the plasminogen (PAI-1) and fibrinogen. 


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