Abstract

LARQUIN COMET, José Ignacio; LEYVA DIVIU, Angelina; LEON RAMENTOL, Cira  and  GARCIA FONTES, Yisel. Acute promyelocytic leukemia. Clinical behavior. AMC [online]. 2008, vol.12, n.6. ISSN 1025-0255.

Background: Acute promyelocytic leukemia is a peculiar form of non- lymphoblastic acute leukemia, with very specific clinical and biological characteristics, that are different from the rest of acute leukemias. Objective: To corroborate the clinical characteristics of acute promyelocytic leukemia taking into account its morphologic varieties, as well as clinical and hematologic manifestations. Method: A descriptive cross-sectional study in the Hematology's department at "Manuel Ascunce Domenech" Teaching University Hospital of Camagüey city was carried out from January 2002 to January 2007. Fourteen patients diagnosed of promyelocytic leukemia were studied and the diagnosis in agreement with Franco American British classification criteria (FAB) was performed, through the realization of the peripheral lamina and the medullary puncture. Results: Main clinical findings were hemorrhage in skin and mucous and fever. Of the total of patients, four sick persons presented complications. Of the universe studied, 11 evolved satisfactorily, three had therapeutic failure and two of them die. Conclusions: All patients showed thrombocytopenia and the half leukocytosis.

Keywords : Leukemia promyelocytic acute [diagnosis].

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