Abstract

RODRIGUEZ LOPEZ, Aquiles José; BALLESTER PEREZ, Arvelio; SALELLAS BRINGUEZ, Julieta  and  EXPOSITO MARRERO, Dania. Antimalarious treatment: an up-to-date review. AMC [online]. 2010, vol.14, n.1, pp. 0-0. ISSN 1025-0255.

With the purpose of offering a panoramic on antimalarial drugs from their emergence until the current situation, an up-to-date review was carried out that includes a brief historical review on the evolution that has experienced the antimalarial treatment from before Christ to date. The introduction of the main drugs in the therapeutic handling of the disease was reflected. The phenomenon of the resistance to the antimalarial drugs as problem to reach the control of this affection was also described, making reference to its definition, classification, factors and mechanisms that intervene, as well as its chronological development and the current world situation concerning to the drug-fast. The main antimalarial drugs currently used with their doses and administration pathways were also shown, and which are the contemporary tendencies that recommend their use. Finally the perspectives that have for the future the antimalarious treatment with the current level of knowledge were related and the last carried out investigations. We concluded that the therapeutic strategies should be based in the existent resistance levels in the different geographical areas, using combinations of antimalarial drugs, mainly those that include some derived of the artemisinin, and if this is not possible at least to use some other combinations rationally according to the resistance level of the region.

Keywords : malaria [therapy]; therapeutics; antimalarials [administration and dosage].

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