Abstract

ARDILA MEDINA, Carlos Martín; BEDOYA GARCIA, Jader  and  GUZMAN ZULUAGA, Isabel Cristina. Association between serum amyloid A pathologic levels and periodontitis. AMC [online]. 2016, vol.20, n.5, pp. 470-476. ISSN 1025-0255.

Background: serum amyloid A protein is produced in response to the cytokines released by monocytes and macrophages after an acute-phase stimulus such as infection. Objective: to determine the serum levels of amyloid A protein and its association with patients diagnosed with chronic periodontal disease. Methods: a cross-sectional observational study was conducted. The universe was composed of 80 patients with chronic periodontitis and 28 people without periodontal affections as a control group. Diagnosis of chronic periodontal disease was based on criteria stated previously. All the participants answered a questionnaire related to sociodemographic characteristics. A clinical enzymatic trial was carried out to calculate the levels of pathological serum amyloid A. Results: pathological levels of serum amyloid A were associated with periodontitis (p=0,002) and were correlated significantly with older age (r=2, 42; p=0, 01). Nevertheless, logistic regression adjusted by age showed remarkable statistical association only with periodontal disease (OR=5, 6; interval from 95 % 1, 7-19). Conclusions: probability of presenting pathological levels of serum amyloid A in patients with chronical periodontal disease is six times the one of the patients without this affection. That could me a risk factor for cardiovascular diseases.

Keywords : SERUM AMYLOID A PROTEIN; CHRONIC PERIODONTITIS; CLINICAL ENZYME TESTS; RISK FACTORS; OBSERVATIONAL STUDY.

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