Abstract

ARDILA MEDINA, Carlos Martín; BERMUDEZ QUINTERO, Margarita Rosa  and  GUZMAN ZULUAGA, Isabel Cristina. Genetic polymorphism as a risk factor in chronic periodontitis. AMC [online]. 2016, vol.20, n.5, pp. 507-513. ISSN 1025-0255.

Background: genetic polymorphisms such as interleukin 1 gene coding for the hyper secretion of certain cytokines to different stimuli, favors the establishment of periodontitis. Objective: to determine the prevalence of interleukin 1 genes and their association with chronic periodontitis in a Colombian population. Methods: in this cross-sectional research, the universe was composed of 108 patients. The diagnosis of mild- moderate to advanced chronic periodontitis was based on pre-defined criteria. Patients with no evidence of these periodontal diagnoses were used as a control group. For determination of the polymorphism of interleukin genes 1 α and β, cheek epithelial cells of the oral mucosa were taken using a swab and a mouthwash. Results: the prevalence of interleukin-1 α and β genes was higher in the group of patients with advanced periodontitis, but no statistically significant differences were observed when compared to the other groups. No statistically significant associations between genes Interleukin 1 α and β with some form of periodontitis were observed. Conclusions: no statistically significant association between interleukin 1 α and β genes and chronic periodontitis was observed, therefore this polymorphism cannot be considered a risk factor for that kind of periodontitis in this population.

Keywords : POLYMORPHISM, GENETIC; CHRONIC PERIODONTITIS; RISK FACTORS; STATISTICAL ANALYSIS; CROSS-SECTIONAL STUDIES.

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