Abstract

PEREZ ESCOBAR, María Mercedes; HERRERA CRUZ, Niria  and  PEREZ ESCOBAR, Elizabeth. Malnutrition-inflammation-atherosclerosis syndrome in terminal chronic kidney disease. AMC [online]. 2017, vol.21, n.3, pp. 409-421. ISSN 1025-0255.

Background: biocompatibility of dialysis that exposes patients to endotoxins and other inductor substances of proinflammatory cytokines, has taken clinical relevance in the hypothesis of the malnutrition-inflammation-atherosclerosis syndrome that associates inflammation to endothelial dysfunction. C-reactive protein is used as a marker of a new type of malnutrition linked to chronic inflammation and the other factors as predictors of cardiovascular diseases. Internationally, cardiovascular diseases are the main causes of death in patients that undergo chronic haemodialysis and constitute the 50 % of these causes; malnutrition, inflammation and atherosclerosis have a direct influence. Objective: to deepen into knowledge of malnutrition, inflammation, and atherosclerosis in patients with last stage chronic renal failure. Methods: a bibliographic research about chronic renal failure and related to malnutrition syndrome, inflammation, and atherosclerosis was carried out in former publications in English as well as in Spanish in the medical literature, after analyzing the data found, the most interesting new and up-dated aspects were summarized. In order to better up comprehension, and organize searching the data was ordered into three main items: malnutrition, inflammation, and atherosclerosis. A total of 66 articles were reviewed, and the 29 most important ones were chosen as references. Conclusions: malnutrition syndrome, inflammation, and atherosclerosis can be responsible for the high morbimortality in patients with terminal stage chronic renal failure.

Keywords : MALNUTRITION; KIDNEY FAILURE, CHRONIC; ATHEROSCLEROSIS; INFLAMMATION; REVIEW LITERATURE AS TOPIC.

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