Abstract

PARADOA, Martha L et al. HLA genes in a sample of the Cuban population. Vaccimonitor [online]. 2000, vol.9, n.3, pp. 1-5. ISSN 1025-0298.

The antigens coded by the HLA genes have a great importance in transplantation, and as genetic markers for anthropological studies, and they are associated to diverse illnesses, in whose pathogenic immunology mechanisms they could be involved. In this study, the distribution of HLA alleles was determined in the Cuban population of Havana City, as a cosmopolitan area 129 healthy blood donors were studied (70 whites, 42 mixed blood (black x white) and 17 blacks), by DNA typing for HLA-A, B, C and DRB1 alleles using PCR and oligonucleotide typing. The gene frequency analysis (GF) of each locus showed the following results: HLA-A * 0201 (23,2%), * 0301 (15,5%), * 2301 (14,7%), * 2402 (14,7%), * 0101 (13,1%) and * 2902 (12,4%): HLA-B * 35 (18,6%), * 44 (17,8%), * 07 (17%) and * 53 (14,7%): HLA-C * 04 (31,7%), * 07 (28,6%), * 0702 (13,9%), * 0602 (13.1) and * 0802 (11,6%): HLA-DR * 02 (27,1%), * 04 (26,3%), * 03 (22,4%), * 11 (22,4%), * 13 (21,7%) and * 01 (13,9%). A high frequency in the distribution of a group of alleles was found. This fact could be related to combinations that give evolutionary advantages against pathogens in our population.

Keywords : HLA; genes; allele; population.

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