Abstract

GONZALEZ, Andrés et al. Booster effect of an active immunization with Leptospira interrogans serogroup Ballum in hamsters vaccinated with vax-SPIRAL®. Vaccimonitor [online]. 2003, vol.12, n.2, pp.1-6. ISSN 1025-028X.

The cross immunity and protective capacity of vax-SPIRAL® against Leptospira interrogans serogroup Ballum, as well as the effect of an active immunization with a Ballum monovalent vaccine in animals previously vaccinated with vax-SPIRAL® were evaluated in hamsters. Specific IgG response against Ballum, Canicola, Icterohaemorrhagiae and Pomona, induced after each immunization was determined by means of a quantitative ELISA. Heterologous protection by vax-SPIRAL® against a challenge with 100 and 10 000 LD50 of two clinical and highly virulent serogroup Ballum strains was also evaluated. Fourteen days after immunization, the trivalent vaccine induced 100% of Ballum specific IgG seroconversion and complete cross-protection against lethal infection and prevalence of leptospires in liver and kidney. A single dose of Ballum monovalent vaccine six weeks after vax-SPIRAL® immunization induced a booster effect on specific immunity against the four most prevalent human Leptospira serogroups in Cuba.

Keywords : Leptospira; Cross immunity; vax-SPIRAL®; Ballum.

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