On-line version ISSN 1025-0298
ESNARD, Sara C et al. Pseudomonas aeruginosa. Vaccines: a challenge to research. Vaccimonitor [online]. 2004, vol.13, n.1, pp. 1-13. ISSN 1025-0298.
Pseudomonas aeruginosa is a gram-negative pathogen, versatile and opportunistic in terms of their physiological and metabolic potential and virulence mechanisms, which is a frequent cause of severe or lethal infections in hospitalized patients over the world The aim to achieve alternative therapies to prevent or combat the infections caused by P. aeruginosa has occupied investigators from all the world since the second half of last century and at the moment works have been reported that support assays of vaccine candidates, starting mainly from protein antigens and based on the construction of recombinant vaccines. In this article a review of published works on research developed in different countries with the purpose to obtain vaccine candidates for the prevention or treatment of the infections caused by Pseudomonas aeruginosa beginning since the decade of the fifties of the 20th century up to the year 2003.
Keywords : Pseudomonas aeruginosa; vaccine candidates.