Abstract

GARCIA, María de los Ángeles; SARMIENTO, María Elena  and  ACOSTA, Armando. The anti-tuberculosis immunity and their implications in the vaccine candidates development. Vaccimonitor [online]. 2009, vol.18, n.1, pp. 25-34. ISSN 1025-0298.

The incidence of tuberculosis has reached alarming rates nowadays. BCG vaccine, the only anti-tuberculosis vaccine available has been inefficient in several field trials around the world. It is currently imperative to obtain new vaccines against tuberculosis. A better understanding of the immune response induced by M. tuberculosis during infection could help to obtain the desired vaccine in a relative short time. The aim of the present review is to show a general panoramic of M. tuberculosis infection cycle , the main effectors cells in the anti- tuberculosis immunity and the fundamental strategies in the rational vaccine development against this disease.

Keywords : Tuberculosis; immunity; vaccine.

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