Abstract

POOLMAN, Jan et al. New generation of outer-membrane vesicles-based meningococcal vaccines . Vaccimonitor [online]. 2009, vol.18, n.2, pp.68-70. ISSN 1025-028X.

With the development of conjugate vaccines, Neisseria meningitidis serogroup B (MenB) will remain the major cause of meningitis, as it is not covered by vaccination. In order to develop a vaccine able to confer a broad cross-protection against invasive MenB strains, we have developed a new generation of outer-membrane vesicles (OMVs) based on the over-expression of well conserved minor outer membrane proteins (OMPs) and the presence of high percentage of detoxified LOS.

Keywords : Neisseria meningitidis; OMV; meningococcal vaccines.

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