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ALVAREZ, Mirta et al. Prescription and surveillance of the sublingual immunotherapy with standardized domestic mite vaccines in allergology service. Vaccimonitor [online]. 2012, vol.21, n.3, pp.13-18. ISSN 1025-028X.

Allergen-specific immunotherapy consists of administering gradually increasing doses of the allergen, to which the patient is sensitized, aiming at achieving tolerance to it and decreasing clinical symptoms. The sublingual immunotherapy (SLIT) was introduced as an alternative to subcutaneous route. The objective was to assess the safety of sublingual standardized vaccines of three domestic mite species (VALERGEN, Cuba) and its adverse events in allergic patients from the Calixto García University Hospital in Havana, as well as the frequency of the vaccine prescription. A descriptive and cross sectional study design included 130 patients with treatment of SLIT with VALERGEN (BIOCEN, Cuba), who attended the Allergy Service in the period from January to September 2010. Age distribution: mean 19.6 years (range 1-75), 40.7% was younger than 18 years. The multiallergen vaccine was the most used (63.8%). The most common allergen was D. pteronyssinus followed by B. tropicalis . 71.55% of administered allergens vaccines were in maintenance phase. We found 4 adverse events (3.1% of patients), all local, mild, and not requiring treatment or change of dosing schedule. The VALERGEN vaccines by sublingual route were shown to be safe and well tolerated in Cuban allergic patients.

Keywords : Immunotherapy; sublingual vaccines; adverse events; VALERGEN; allergy.

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