SciELO - Scientific Electronic Library Online

vol.22 issue3Neuroimmunological response in dengue virus encephalitis author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO



Print version ISSN 1025-028X


RIBAS, María de los Angeles et al. Identification of primary and secondary infection to rubella virus by the detection of IgG avidity in samples of an outbreak occurred in 2004 in Cuba . Vaccimonitor [online]. 2013, vol.22, n.3, pp.4-8. ISSN 1025-028X.

Rubella infectious diseases affect children and young adults and when they occur during the first trimester of pregnancy, cause congenital malformations in the newborn. In the National Reference Laboratory (NLR) of measles, rubella and mumps from the Tropical Medicine Institute ¨Pedro Kourí¨, the IgG Avidity Index (AI) detection was carried out to 15 paired serum samples, which corresponded to same number of patients infected with this virus in two Cuban provinces in 2004. The samples were positive to virus- specific IgM antibodies, in addition seroconversion or an increase of > 4 fold of the titers in the sera of the acute and convalescence phase using the hemagglutination inhibition assay (HIA). The AI value showed a primary infection to rubella virus in 13 (86.6%) of the patients studied, and a secondary infection in 2 (13.3%) of them. The IgG avidity antibody detection is a reliable alternative tool for distinguishing between primary and secondary rubella virus infection and for strengthing the diagnosis of this disease in Cuba

Keywords : rubella; avidity; ELISA; IgG.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License