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Vaccimonitor

Print version ISSN 1025-028XOn-line version ISSN 1025-0298

Abstract

OCHOA-AZZE, Rolando  and  GARCIA-IMIA, Luis. Effectiveness of VA-MENGOC-BC® vaccine against heterologous strains of meningococcus B. Vaccimonitor [online]. 2016, vol.25, n.2, pp.43-48. ISSN 1025-028X.

Vaccines based on outer membrane vesicles of Neisseria meningitidis serogroup B strains have been questioned by some researchers, who limit its effectiveness to the vaccine strain. VA-MENGOC-BC® is a meningococcal vaccine based on this technology. A meta-analysis of independent studies in different epidemiological contexts is used to assess the clinical effectiveness of the vaccine against heterologous serogroup B strains in several age groups. In this paper we provide evidence supporting its effectiveness against homologous and heterologous strains from different clonal complexes.

Keywords : Neisseria meningitidis; meningococcal disease; vaccines; serogroup B.

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