Abstract

CASTILLO-GONZALEZ, William; GONZALEZ-LOSADA, Cristóbal; IGLESIAS-GONZALEZ, Ivonne Margarita  and  DORTA-CONTRERAS, Alberto Juan. Immuno-epidemiological inquiry in children suffering viral meningoncephalitis vaccinate against mumps, rubella and measles. Vaccimonitor [online]. 2019, vol.28, n.1, pp.19-28. ISSN 1025-028X.

Paramixovirus like mumps, rubella and measles are involved in some viral meningoencephalitis. Triple combined vaccines have been employed for several years in many countries. The aim of this work is to determine the IgG anti mumps, rubella and measles polyspecific response in pediatric patients with acute viral meningoencephalitis. A 2018 retrospective study in pediatric patients with acute viral meningoencephalitis previously vaccinated with the triple viral vaccine MMR was performed to identify the immune response status against mumps, rubella and measles in samples from LABCEL serum and cerebrospinal fluid collection. Quantification of IgG specific antibody was performed by ELISA. Intrathecal polyspecific response was present in all patients. A significant decrement of anti IgG mumps specific antibody index was observed according to age and response time. A shortage of the response time of IgG mumps specific antibodies according to the age of vaccination was demonstrated.

Keywords : MMR vaccine; rubella; mumps, measles; reibergram.

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