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Biotecnología Aplicada

On-line version ISSN 1027-2852


GIL DEL VALLE, Lizette et al. Characterization of oxidative stress in different clinical conditions, using redox indexes of diagnostic value. Biotecnol Apl [online]. 2012, vol.29, n.3, pp.175-183. ISSN 1027-2852.

The redox status imbalance could be related to diverse clinical entities. Recognized analytic methodologies quantifying both: oxidative biomolecular damage and antioxidant activity were used for the characterization of redox balance in human samples (urine, lymphocytes, plasma and serum) in relation with progression markers of diverse clinical conditions. Case and control studies of Human immunodeficiency virus (HIV), Dengue, Diabetes mellitus (DM) type 1, Human-T lymphotropic virus type-1 patients and apparently healthy individuals (18-84 years) were carried out. The evaluation was also applied in intervention designs. The results evidenced oxidative alterations and antioxidant capacity decreased significantly (p < 0.05) in patients compared to healthy individuals related in age and gender. Studies of nutritional intervention and antioxidant supplementation with Vimang(r) in 40 and 81 HIV Cuban patients respectively showed significant beneficial changes (p < 0.05) in 56% and 43.9% of cases respectively. An observational study in 56 HIV Cuban patients was carried out involving two combinations of antiretroviral therapy. The study showed evidences of oxidative modifications significant (p < 0.05) in 87% of the cases, finding differences among combinations. An observational study involving 40 Cuban DM type 1 patients with change of neutral protamine Hagedorn insulin from pig to human recombinant, showed a significant beneficial change (p < 0.05) in 81% of the cases after the change. The integral characterization could be useful for follow up and individuals' management but also contribute to the knowledge of the molecular mechanisms underlying in these illnesses.

Keywords : oxidative stress; HIV; HTLV-1; diabetes type 1; dengue; integral diagnosis.

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