Abstract

RAMIREZ-SUAREZ, Anna; PANEQUE-GUERRERO, Taimí; CASILLAS-CASANOVA, Dionne  and  FERNANDEZ-ORTEGA, Celia. Remarks on the Conference HIV pathogenesis, virus versus host, Alberta, Canada, March 9-14, 2014. Biotecnol Apl [online]. 2014, vol.31, n.4, pp.323-327. ISSN 1027-2852.

Combined anti-retroviral therapy has been really efficient in suppressing HIV replication, but it does not cure the infection. This is due to the permanency of integrated viral DNA in the infected cells. To achieve the HIV cure, the interaction between virus and its host needs to be extremely understood. Because of this, scientific community persists in dedicating efforts to profoundly comprehend the pathogenesis of this virus. The present work summaries important aspects discussed in the last meeting HIV-Pathogenesis, Virus vs. Host. It was held in Fairmont Banff Springs, Banff, Alberta, Canada, March 9-14. The conference debated the latest advances in the biology of HIV-1. Topics as virus entry into the cell, into the host, virus exit, virushost genetics and co-evolution, host-virus interactions and responses, reservoirs, latency, reactivation, HIV and central nervous system, animal models and HIV and the microbiome at the mucosa were updated and deeply discussed. In parallel HIV vaccines: Adaptive Immunity and Beyond meeting was celebrated. The event, part of the Keystone Symposia Global Health Series, was a singular opportunity to analyze the state of HIV research and the new challenges in the battle against HIV infection.

Keywords : HIV-1; pathogenesis; latency; reservoirs; cure; eradication.

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