SciELO - Scientific Electronic Library Online

vol.32 issue1Pharmacological applications and in vitro biotechnological production of anticancer alkaloids of Catharanthus roseusEvaluation in vitro of the cytotoxicity and genotoxicity of silica nanoparticle aggregates synthesized by the sol-gel method author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Biotecnología Aplicada

On-line version ISSN 1027-2852


DORTA-GURIDI, Zaily et al. Therapeutic vaccines against the hepatitis C virus in the age of direct-acting antivirals. Biotecnol Apl [online]. 2015, vol.32, n.1, pp.1121-1124. ISSN 1027-2852.

Hepatitis C is a significant health problem worldwide, with incidence estimates around 160 million people and 500 000 annual deaths. The limited success of treatments in chronic genotype 1 hepatitis C virus (HCV) patients and the numerous and significant adverse effects of the therapeutic treatment with pegilated interferon and ribavirin have encouraged the development of different direct-acting antivirals (DAAs) with promising results. This was also stimulated by advances of the knowledge on virus cell cycle and the properties of its structural properties. However, DAAs are very expensive and some of those compounds have developed multiple adverse events, all these limiting their use in certain infected populations. Moreover, its use does not prevent from HCV reinfections. Hence, new treatments, such as therapeutic vaccines, have arisen as additional or combined therapies against chronic HCV infection.

Keywords : hepatitis C virus; chronic infection; therapeutic vaccine; antiviral therapy.

        · abstract in Spanish     · text in English     · English ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License