Abstract

BARRIO ALONSO, Gloria del  and  ROQUE QUINTERO, Annele. Inactivación del agshb por un extracto de phyllanthus orbicularis. Rev Cubana Plant Med [online]. 1999, vol.4, n.3, pp.95-97. ISSN 1028-4796.

Some species of Phyllantus gendre have showed in vitro and in vivo activity to hepatitis B. In present paper, we assess inactivation capacity on AgsHB from aqueous extract of endemic Phyllanthus orbicularis species. Authors analyze 4 concentrations of extract (100, 50, 25, 12,5 mg/mL) as opposed to 34 positive sera to this marker. All concentrations assayed showed ability to decrease value of optic density in more than 60 % of sera studied, while percent of sera becoming negatives, was of 88,2 %, 97,1 % 50 %, and 8,8 %, respectively. In concentration of 12,5 mg/mL there was not statistically differences with regard to controls; while concentrations of 100 mg/mL and 50 mg/mL, which weren't statistically different each other, were the most effective ones. These results show that aqueous extract of P. orbicularis present one o some compounds, able to inactivate in vitro AgsHB.

Keywords : HEPATITIS B SURFACE ANTIGENS [drug effects]; PLANT EXTRACTS [pharmacology]; PLANTS, MEDICINAL.

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