Abstract

GONZALEZ TORRES, Yana et al. Toxicity assay at repeated doses of Cecropia peltata L. (yagruma) aqueous extract in Cenp: SPRD rats during 28 days. Rev Cubana Plant Med [online]. 2006, vol.11, n.2. ISSN 1028-4796.

The aqueous extract of Cecropia peltata is made from a plant commonly called yagruma or guarumo in Cuba. This extract is used in the manufacture of tablets with bronchodilator action. This plant has antiasthmatic, antiblennorrheal, analgesic, and healing effects, among others. The assay was carried out to assess the toxic features of this aqueous extract and its toxic effects in rats. An oral dose of 1000 mg of total solids/kg of body weight was administered for 28 days. The animals were daily observed to detect signs of toxicity. At the end of the treatment hematology and blood chemistry tests were done and necropsy was performed to make the corresponding anatomopathological and histopathological examination. No affectations were reported in body weight and food consumption. The results attained by the histopathological examination confirmed all the above.

Keywords : Repeated dose; Cecropia peltata ; toxicity; rats.