Abstract

BELLMA MENENDEZ, Addis et al. Evaluation of Cucurbita pepo L. lipophilic extract on androgen-induced prostatic hyperplasia. Rev Cubana Plant Med [online]. 2006, vol.11, n.2. ISSN 1028-4796.

Oil from pumpkin seeds has been widely used in the treatment of prostatic hyperplasia. In the present paper, the effect of lipophilic extract of Cucurbita pepo L seeds (ELMSC) was studied in an in vivo model of testosterone propionate -induced experimental prostatic hyperplasia during 15 days. It was found that ELMSC at doses of 400 and 200 mg/kg caused a significant decrease of prostatic growth. Our findings showed that doses of ELMSC over 200 mg/kg inhibits the testosterone-induced prostatic growth in the experimental model of prostatic hyperplasia in rats.

Keywords : Experimental prostatic benign hyperplasia; Cucurbita pepo L..