Abstract

NUNEZ FIGUEREDO, Yanier et al. Activity of Plectranthus amboinicus (Lous.) Spreng 100 mg tablets on the intestinal smooth musculature. Rev Cubana Plant Med [online]. 2006, vol.11, n.3-4, pp. 0-0. ISSN 1028-4796.

In the present paper, the effects of Plectranthus amboinicus (Lour.) Spreg (French origan) 100 mg tablets on the smooth musculature, as well as their influence on the cholinergic transmission were evaluated by using male Hartley guinea pigs with 200 to 250 g of body mass for extracting different portions of ileum. It was observed that the P. amboinicus (Lour.) Spreg, 100 mg tablets at the different assessed concentrations provoked an immediate contraction of the smooth musculature. The French origan showed a marked antimuscarinic effect against Acethylcholine-induced contractions (ACh) from 10-6 to 10-3 M. The combined administration of P. amboinicus (Lour.) Spreg 10 mg/mL and ACh 10^-3 M did not surpass the contraction induced by the latter in a independent way, whereas atropine 3 x 10-12 M decreased the contractions produced by different concentrations of French origan and ACh 10-3 M. That is why, the evaluated tablets present an agonist and antagonist effect of the cholinergic transmission.

Keywords : Plectranthus amboinicus (Lour.) Spreng; French origan; antimuscarinic; ileum; bronchial asthma.