Abstract

MARCHIORI MARIANI, Paula et al. Chemopreventive and antimutagenic potential in vivo of hydroethanolic fruit extract of Carica papaya L.. Rev Cubana Plant Med [online]. 2013, vol.18, n.3, pp. 381-390. ISSN 1028-4796.

Introduction: the fruits of Carica papaya L. are widely consumed around the world and in Brazil, but little is known about its cytotoxic, antimutagenic and chemoprotector effects. Objectives: to evaluate the antimutagenic and chemoprotector potential of fruits of Carica papaya and quantify the phenolic substances present in those fruits. Methods: mutagenic activity was evaluated by micronucleus assay and phenolic substances were analyzed by the Folin-Ciacalteau method (total phenolics), and by aluminum chloride colorimetric method (total flavonoids). Results: the hidroetanolic extract of fruits of Carica papaya elicited antimutagenic and chemoprotector effects (370 mg/100 g body weight). The content of phenolic substances of hidroetanolic extract of fruits was lower than 0.001 µg/mg. Conclusions: the antimutagenic and chemoprotector effects observed must be related to other compounds. Chemical studies must be conducted to identify the substances involved in the activity.

Keywords : Carica papaya L.; micronucleous assay; phenolic compound.

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