Abstract

NUNEZ COPO, Antonio César; FROMETA MONTOYA, Carmen Iliana  and  RUBIO GONZALEZ, Tamara. Environmental and genetic factors associated with breast cancer in women from "28 de Septiembre" health area. MEDISAN [online]. 2011, vol.15, n.2, pp.162-169. ISSN 1029-3019.

Breast cancer, for the number of diagnosed patients and those dead by this cause, is in one of the first positions in the world and also in Cuba; reasons why an analytic observational case-control study in "28 de Septiembre" health area of Santiago de Cuba was carried out from January to April 2009, which included 40 women with breast cancer (considered as cases), who were recorded in the Service of Breast Pathology and selected by a simple random sampling, as well as 80 controls without this diagnosis, to determine possible environmental and genetic factors influencing the occurrence of this malignancy. The chi-square test was performed with a significance of 0,05, and odds ratio was calculated to evaluate the extent of association between variates and by confidence interval. An association of family medical history of this type of cancer was found in the cases, particularly in first-degree relatives and more significantly in the group with this disease, in which disease family aggregation was also observed more commonly. It is concluded that this malignancy was more frequent en women between 51 and 65 years with late menopause and toxic habits.

Keywords : woman; breast cancer; environmental and genetic factors; family aggregation; primary health care.

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