Abstract

GONZALEZ GILART, Gretel  and  SALMON GAINZA, Sorge Leyn. Hydroxyurea in the treatment of children and adolescents with sickle cell anemia. MEDISAN [online]. 2012, vol.16, n.6, pp. 881-887. ISSN 1029-3019.

A study of therapeutic intervention was carried out, in order to determine the clinical improvement and laboratory results in 163 children affected by sickle cell anemia and who were treated with hydroxyurea, and who were assisted in the Southern Children Hospital in Santiago de Cuba from September, 2009 to the same month of 2010. For this, an intentional sample of 22 patients was selected, taking into account the inclusion and exclusion criteria, number of clinical events, laboratory parameters, transfusions and admissions in a year with the use of the medication. After some months of initiating the treatment, they were compared with the same indicators. When concluding the investigation it was verified that hydroxyurea had increased the fetal hemoglobin levels and decreased the occurrence of clinical events, among which there were: vasoocclusive and central nervous system crisis, acute thoracic syndrome and infections.

Keywords : child; hydroxyurea; sickle cell anemia; vasoocclusive crisis; acute thoracic syndrome; central nervous system; children hospital.

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