Abstract

FONG LORES, Onel; BERENGUER RIVAS, Clara Azalea; PUENTE ZAPATA, Edgar  and  SALAS MARTINEZ, Hilario. Spontaneous abstinence in mice treated with Mimosa pudica. MEDISAN [online]. 2014, vol.18, n.2, pp.193-199. ISSN 1029-3019.

The plant Mimosa pudica (moriviví, as it is commonly known), has been traditionally used as anesthetic, antidepressant, sedative, antialopecic, among other pharmacological properties; however, in the last years its use has become excessive. With the objective of knowing the addictive potential of this plant a trial of spontaneous abstinence was developed in mice of the strain NMRI, carried out during 20 days, for which a dose of 1 000 mg/kg of weight of the decoction of the plant was administered orally twice at day. As negative and positive control water and morphine were used (32 mg/kg of weight intraperitoneally, in both cases). Finally, it was shown that this decoction showed signs of physical dependence and the animals in study showed a decrease of the body weight and an increase of the rectal temperature with regard to the negative control, once the decoction was discontinued. On the other hand, these signs were more significant in the positive control, so that it can be stated that the decoction of the plant Mimosa pudica evidenced signs of physical dependence with the used dose.

Keywords : Mimosa pudica; addiction; trial of spontaneous abstinence; morphine.

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