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On-line version ISSN 1029-3019


CARBONELL AMIOT, Tania Delia; CASTRO ANDION, Liudmila Risset  and  LUBIN GARCIA, Ana. Evaluation of endothelial dysfunction for cardiovascular risk prediction. MEDISAN [online]. 2023, vol.27, n.6  Epub Dec 15, 2023. ISSN 1029-3019.


Cardiovascular diseases constitute the first death cause worldwide, reason why the identification and modification of associated risk factors constitute prioritized strategies by the World Health Organization. To have a prediction model of cardiovascular risk enriched with the evaluation of the endothelial dysfunction would influence positively in these goals.


To identify the presence of endothelial dysfunction in patients with or without cardiovascular diseases and to determine the association between them.


An observational and descriptive cases series study was carried out in the Cardiology and Cardiovascular Surgery Center at Saturnino Lora Teaching Clinical Surgical Provincial Hospital in Santiago de Cuba, from January, 2022 to the same month, 2023, where the traditional cardiovascular risk factors and endothelial dysfunction biomarkers were analyzed as variables. Secondarily, an analytic case-control study was carried out in which multivariate binary logistic regression was applied.


The presence of endothelial dysfunction associated with the onset of cardiovascular diseases was confirmed, what was evaluated through the vasodilatation index, mediated by the brachial artery flow and the fibrinogen plasmatic concentrations.


The clinical and epidemiological pattern of patients with or without cardiovascular diseases did not differ from that reported in the specialized literature on the base of the identification of traditional risk factors.

Keywords : cardiovascular diseases; risks facts; vascular endothelium; risk forecasting.

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