Abstract

FERRER CASERO, Eduardo A; WILSON CORREA, Tania; GUERRERO ARRANZ, Jaime  and  MOYA GONZALEZ, Noel. Dengue and Teratogenic Factors. Report of a Patient. ccm [online]. 2017, vol.21, n.3, pp.908-916. ISSN 1560-4381.

A case of spontaneous abortion occurred between the tenth and eleventh weeks of gestation in a pregnant woman during the dengue epidemic that affected the city of Holguín in 2015. The objective of this was to analyze of the teratogenic factors that affected the gestational failure. The transplacental transmission of dengue virus infection to embryofeto, which caused alterations in the metabolic process of the embryofoetal development, was the primary teratogenic factor, together with the prolonged febrile exposure that affected the pregnant woman, with the formation of a retroplacental hematoma, and secondary variable degree of placental insufficiency, causing the abortion. Dipyrone, gravinol, omeprazole, diphenhydramine and benadryline were the pharmacological therapy used,  due to the insufficient microsomal and cytosolic enzymatic activity, characteristic at this stage of conception development, has usually interrupted or hindered the embryofoetal pharmacokinetic activity, acting as coteratogen, influenced in the development of conception to produce embryolethal effects, producing the spontaneous abortion.

Keywords : dengue virus; embryo; fetus; abortion; teratogen; coteratogene; anembrionic pregnancy.

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