Abstract

GONZALEZ SUAREZ, Roberto M.; PERICH AMADOR, Pedro; VALDES RAMOS, Eduardo  and  ARRANZ CALZADO, Celeste. Metabolic factors associated with the progression of diabetes mellitus in subjects with impaired glucose tolerance. Rev Cubana Endocrinol [online]. 2007, vol.18, n.3, pp. 0-0. ISSN 1561-2953.

A prospective study was conducted in 84 patients with impaired glucose tolerance (IGT) diagnosed 18 years before to identify metabolic factors found in the initial study that could be associated with the progression to diabetes mellitus (DM) detected in the evolutive study. The severity of the glucose tolerance disorder, the reduction or increase of insulin secretion on fasting or during an oral glucose tolerance test (OGTT), as well as the resistance to insulin detected on fasting or during the OGTT, were considered as risk factors. All of them were determined by methods and criteria of interpretation that were previously established and validated. It was observed that a low initial insulin response (reduced II0-30) was significantly associated with the progression to diabetes in the group of studied individuals with IGT. This finding was consistent with all the aspects of the evaluated phenomenon (absolute values of the variables in the group of subjects classified according to their evolution, risk of evolution toward diabetes mellitus and time elapsed until the diagnosis of DM) and agreed with the criteria that the genetically determined factor that conditions the development of DM is a defect   of the initial capacity of the insulin secretory response to glycaemia changes.

Keywords : Non-insulin dependent diabetes mellitus (reduced II0-30); glucose intolerance; glucose tolerance test; risk factors; insulin resistance; reduced insulin secretion.