Abstract

NAVARRO DESPAIGNE, Daysi; SANTANA PEREZ, Felipe; PADRON DURAN, Rubén  and  CABRERA GAMEZ, Maité. Hormones of the hypothalamic-hypophyseal gonadal axis and climacteric syndrome. Rev Cubana Endocrinol [online]. 2007, vol.18, n.3, pp. 0-0. ISSN 1561-2953.

The clinical manifestations of the climacteric syndrome (CS) are considered as an expression of the endocrine changes following the cessation of the reproductive function, so there must be a relation between the intensity of the CS and hypoestrogenism or the gonadotropin levels. In order to connect the levels of estradiol and gonadotropins with the intensity of the climacteric syndromes, a descriptive cross-sectional study was conducted from September 2005 to August 2006 in a group of 48 healthy postmenopausal females aged 41-59, without  replacement therapy treatment, from the Climacteric and Osteoporosis Clinic of the National Institute of Endocrinology. Pérez Piñeiros scale was used to evaluate CS. The plasmatic levels of FSH and LH were determined by IRMA and those of estradiol by RIA. The mean, standard deviation and median were used. Wilcoxons sign rank test and Mann-Whitneys test were applied. The mean of the FSH levels was 77.0 UI/L, whereas that of the LH levels was 37.7 UI/L. The mean levels of estradiol were 14.8 pmol/L. As to the intensity of the climacteric symptoms, the mild degree was the most common (50 %), followed by the moderate (33.3 %) and the severe (16.7 %). No correlation was found between the levels of gonadotropins or estradiol and the severity degree of the climacteric syndromes. It was not proved that the hormonal pattern of the hypothalamic hypophyseal ovarian axis influenced on the intensity of the climacteric symptoms after menopause.

Keywords : : Climacteric syndrome; gonadotropins; estradiol.