Abstract

GONZALEZ FERNANDEZ, Pedro et al. Characterization of the metabolic control in children and adolescents with type I diabetes mellitus. Rev Cubana Endocrinol [online]. 2012, vol.23, n.2, pp. 117-127. ISSN 1561-2953.

Introduction: the metabolic control is the main objective of the diabetes mellitus treatment. Objective: to characterize the metabolic control in a group of children and adolescents with type I diabetes mellitus. Methods: a prospective study was conducted in 84 patients with type 1 diabetes mellitus, who had been seen at the endocrinology service of "William Soler" university pediatric hospital from February 2010 to August 2011. Glycated haemoglobin (HbA1c) was estimated in a period of 90 to 120 days. The quantitative turbidimetric method served to determine hemoglobin A1c by using Futura System reagent. The quarterly results of HbA1c were compared by age, sex, time of evolution of diabetes mellitus, body weight in kg and total daily dosage of insulin. Results: the average age of male patients was 11.6 years (SD= 4,6) and of female patients was 12.4 years (SD= 4.5). The mean age at the beginning of the study was 12.23 years (SD= 4.42) and the mean age at time of diagnosis was 8.27 years (SD= 4.28). The average time of evolution for diabetes was 3.79 years (SD= 3.17) and the daily mean dose of insulin per kg of bodyweight was 0.91 units (SD= 0.26). The HbA1c values were kept over 10 %, except for the two last estimations that showed significantly lower values than those of previous months and were not dependent on the variables sex, time of evolution, age at time of diagnosis and daily average dose of insulin per kilogram of bodyweight. Conclusions: adequate clinical relation and improved adherence to treatment are decisive elements for the improvement of the metabolic control in these patients.

Keywords : type 1 diabetes mellitus; diabetes in children; metabolic control; glycated hemoglobin; HbA1c; clinical relation; adherence to treatment.

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