Abstract

CRUZ HERNANDEZ, Jeddú et al. Endothelial dysfunction and diabetes mellitus. Rev Cubana Endocrinol [online]. 2012, vol.23, n.2, pp. 166-185. ISSN 1561-2953.

Introduction: endothelial dysfunction frequently appears in individuals with diabetes mellitus, because vascular alterations derived from chronic hyperglycemia facilitate the occurrence of the disease, to which blood hypertension and dislipidemia of diabetics also contribute. Objective: to describe some events involved in the onset of endothelial dysfunction in diabetes mellitus and several aspects related to diagnosis and treatment. Development: among the most important markers of endothelial dysfunction in diabetes mellitus are the rises of cell adhesion molecules and inflammation markers, microalbuminuria, hyperhomocysteinemia and the increase of glycated hemoglobin, of endothelin-1 and of oxidative stress. For the diagnosis, one uses the measurement of regulating substances of biofunctions synthesized by the endothelium and by others recognized as endothelial dysfunction markers, and indirect tests some of which are invasive. For the treatment, various therapeutic methods, either drug-based or not, are used. Conclusions: it is important to early identify endothelial dysfunction in diabetics and treat it as appropriate.

Keywords : endothelial dysfunction; diabetes mellitus.

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