Revista de Ciencias Médicas de Pinar del Río
On-line version ISSN 1561-3194
PEREZ VALDIVIA, Jorge; GONZALEZ LOPEZ, Ileana; IGLESIAS IGLESIAS, Modesto A and GARCIA RUIZ, Jorge E. Contractibility of the ventricular muscle under the action of prajmaline-propanolol and prajmaline-epinephrine. Rev Ciencias Médicas [online]. 2005, vol.9, n.1, pp. 31-40. ISSN 1561-3194.
The effects of alfa and beta adrenergic stimulation can be accomplished by agonist and antagonist agents such as epinephrine and propanolol respectively. Aimed at determining the aspects related to contractibility of ventricular muscle, thirteen experiments were performed using combinations of prajmaline "epinephrine and prajmaline" propanolol, being perfused preparations of ventricular muscle strips of thirteen samples of adult Catesblian frogs. Prajmaline, a group I antiarrhythmic, was obtained from Rauvvolfia viridis, an endemic plant in Cuba. The preparations were stimulated with electric current pulses and the tension performed by the muscle was registered by a force "displacement transductor". The electric signals were transformed into lines by a registering equipment. The results suggest that prajmaline "epinephrine and prajmaline" propanolol combinations affect diametrically opposed to contractibility of cardiac muscle, increasing by 40 % and decreasing by 15 %, respectively, the force of contraction of ventricular muscle. Alternatively, a potential mechanism of prajmaline action is suggested on alfa receptors present in the ventricular cell membranes.
Keywords : CATESBEIANA; SYMPHATHOLYTIC.