Abstract

NARANJO RODRIGUEZ, Sandra Adela; GARCIA MENENDEZ, Rodobaldo; NARANJO RODRIGUEZ, Lisandra  and  NEGRET HERNANDEZ (1), Marisel. Immunotherapy employment in patient with infection produced by Staphylococcus aureus. Rev. Med. Electrón. [online]. 2011, vol.33, n.2, pp.189-195. ISSN 1684-1824.

SUMMARY The skin infection by Staphylococcus aureus is currently a health problem in our population, because of its high frequency, resistance to the antibiotic therapy and its complications. We carried out a randomized, open, controlled, phase II clinical trial, with the objective of demonstrating the therapeutic effect and safety of the autovaccine as a treatment of the Staphylococcus infections. 457 patients with a diagnosis of Staphylococcus aureus in skin lesions were included, and they were divided in two groups. Group A (237 patients), received the autovaccine obtained form the micro organism isolated in each subject, and group B (220 patients), received antibiotic treatment according to the antibiogram results. With the application of the autovaccine, we obtained 82 % of healing, and only 10 % of the patients had the reappearance of furuncles in an interval of 6 months after finishing the treatment. However, with the application of the antibiotic therapy there was 12 % of healing and 75 % of reappearance of the furuncles in the mentioned time interval. The autovaccine was more effective in the treatment of the bacterial infection by Staphylococcus aureus that the antimicrobial agents besides being a good tolerated immunotherapy for most of the patients.

Keywords : skin diseases infectious; Staphylococcus aureus; immunotherapy; autovaccines; clinical trial phase II; treatment outcome.

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