Abstract

RUFIN-GOMEZ, Lorenzo Ángel et al. Pathogenic effects of advanced glycation end products in aging-disease process. Rev.Med.Electrón. [online]. 2022, vol.44, n.3, pp. 573-584.  Epub June 30, 2022. ISSN 1684-1824.

The advanced glycation end-products-known like products of the Maillard reaction-formed by a direct non-enzymatic glycation of reducing sugars with amino groups free of proteins, cause structural and functional changes in them, whose endogenous production is incremented with age, oxidative stress, as well as by external factors, causing premature aging and degenerative diseases. The objective of the review objective was to obtain an updated view of the advances in research on the effects of the advanced glycation end products and their interrelation with the oxidative stress in the aging-disease process. In the review the authors considered the most recent leading articles on the topic published in the databases PubMed, SciELO, ClinicalKey and LILACS. The pathogenic effects of the advanced glycation end products that contribute to oxidative stress and inflammation are evidenced, especially in premature aging, diabetes, cardiovascular disease and other neurodegenerative diseases, as a worrying aspect in the issue of population aging and its enormous cost for future society.

Keywords : advanced glycation end products; glycotoxins; premature aging; diabetes mellitus; oxidative stress; neurodegenerative diseases.

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