SciELO - Scientific Electronic Library Online

vol.12 issue2Subcutaneous Post-mastectomy Breast Reconstruction with Wise Marking Pattern. A Case ReportBone Metastasis as a Presentation of Hodgkin's Lymphoma. A Case Report author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista Finlay

On-line version ISSN 2221-2434


VALLADARES VALLE, Masleidy; GARCIA LEONARD, Juan Ibrahim  and  SANCHEZ LOZANO, Ada. Marchiafava-Bignami Disease: a Reality. A Case Report. Rev. Finlay [online]. 2022, vol.12, n.2, pp.239-244.  Epub June 30, 2022. ISSN 2221-2434.

Marchiafava-Bignami disease has been recognized as a syndrome characterized by necrosis and focal demyelination of the corpus callosum. It was first described in 1903 by the pathologists Marchiafava and Bignami in three Italian alcoholic patients who drink red wine. The case of a 55-year-old patient is reported, alcoholic, who attended with generalized epileptic seizures and impaired level of consciousness. Magnetic resonance imaging of the skull revealed demyelination of the corpus callosum, white and gray matter of the parietal and frontal lobes, leading to the diagnosis of acute Marchiafava-Bignami type A disease. The patient died of hospital-acquired pneumonia 15 days later of income. Knowledge of this disease is necessary, because despite the poor prognosis of its acute form, cases of good evolution with timely diagnosis and treatment are reported. The case is presented with the aim of evidencing the diagnosis of a rare disease that can be expressed in a variable way and qualifies as a medical emergency.

Keywords : marchiafava-bignami disease; magnetic resonance; case report.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )