Abstract

GUERRA COLLAZO, Gabriela et al. PRELIMINARY STABILITY STUDY OF TWO CREAMS FOR ACNE TREATMENT. Rev. CENIC Cienc. Quím. [online]. 2023, vol.54, pp. 44-51.  Epub Sep 01, 2023. ISSN 2221-2442.

Among the factors currently identified in the appearance of acne is the bacterial proliferation of Cutibacterium acnes due to seborrhea and hyperkeratosis. Topical acne treatments are strictly necessary and range from antibiotics to salicylic acid depending on the type of acne to be treated. The main mechanisms of action of topical products for this disease are aimed at eliminating excess bacteria from the skin and reducing the process of redness and inflammation. For the treatment of this disease, two creams were developed using two concentrations of topical OLEOZON® as active pharmaceutical ingredient, with polysorbate 80 as emulsifying agent and other excipients. A stability study was performed for six months, which showed its behavior at the two storage temperatures (2-8˚C and 30˚C) from the organoleptic, physicochemical and microbiological point of view, the latter showed a marked antimicrobial activity and absence of microorganisms in the samples during the six months of study. The organoleptic properties showed better results at low storage temperatures, since they remained uniform in terms of color, odor and texture; likewise, the physicochemical evaluation corroborated a better performance for the creams stored at low temperatures.

Keywords : cream; acne; stability; formulation; ozonized oil.

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