Abstract

RODRIGUEZ-IZQUIERDO, Julio Ricardo et al. Nanoparticles of Gd₂O₃ pegylated and conjugated to amylovis with potential application in the detection of alzheimer by MRI. Rev Cub Quim [online]. 2021, vol.33, n.2, pp. 3-22.  Epub Apr 26, 2021. ISSN 2224-5421.

Specific contrast agents facilitate the use of Magnetic Resonance Imaging (MRI) in the early diagnosis of Alzheimer's disease (AD). In the present work, a procedure for the synthesis of a potential MRI contrast agent based on PEGylated Gd2O3 particles is developed for conjugation to Amylovis®, a family of compounds that has shown a high affinity for the pathological structures present in AD. The products obtained were characterized by FT-IR, ICP, TGA, DLS and SEM. Amylovis-functionalized Gd2O3 particles showed a spherical morphology, with an average hydrodynamic diameter of 2.5 μm. These particles presented an adequate value of the ratio between the longitudinal (r1) and transversal (r2) relaxivities (r2/r1 = 2.4). This suggests that once these particles have a hydrodynamic diameter smaller than 200 nm, they could be used as a potential contrast agent for MRI.

Keywords : alzheimer disease; contrast agent; nanoparticles; gadolinium oxide; MRI.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )