Abstract

CALDERON REZA, Juan Carlos. COLON CANCER, ADENOMA CARCINOMA SEQUENCE AND SERRATED POLYP. Conrado [online]. 2018, vol.14, n.62, pp. 52-55. ISSN 1990-8644.

Adenomatous polyps are very common and pose great potential for malignant transformation. Between them the velloso is the of greater potential malignant, but all them types histological presented component villous in greater or lesser proportion, by what all is can consider premalignant, this process degenerative known as sequence adenoma carcinoma explained effectively a 85% of them cancers colorectal by decades. Today thanks to technological advances, is known that not all colorectal cancers are the above sequence, the remaining 10-15%, are included within the so-called "Serrated neoplasia pathway whose characteristic is microsatellite instability, characterized by the inactivation of the DNA repair genes by epigenetic changes as the promoter hypermethylation of the MLH1 gene observed in the syndrome of Lynch.

Keywords : Polyps; Adenomas; serrated polyp; malignancy; surveillance.

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